Some USB slots may be defective. This can happen either at the USB slot end or at the USB motherboard headers end. Wear and tear at the USB slot end is also another factor.
For info, on my latest build, one of the two USB3 front ports does not work at all; the other one works fine. This could be at either end on the USB3 cable that connects to the motherboard. On an older desktop, the from USB2 ports are bad due to wear, and I use the rear USB2 ports along with a USB2 extension cable.
Try a different device and see if anything changes.
USB2 has a power limitation, and sometimes devices that require a slightly higher power will not work on the USB port. This is also a factor. My Toshiba (brand does not matter) USB2 external drive will work on some computers and not on others.