Well, first thing is you don't need 2 cards to run 2 monitors, just about any modern day card will run 2-3 monitors. If you are asking if you can run Crossfire or SLI with 2 cards and run multiple monitors, then the answer is yes. I know you can run Eyefinity on 2 monitors, and I'd assume you could do the same with Nvidia cards. You wouldn't want to run games on 2 monitors though, many games like first and third person games will be a nightmare to play since there will be a split right down the middle, usually where the crosshairs are.