Answer is a definite Maybe....there's no guarantees, and the other hardware plays into how they might run, if the mobo can utilize flex mode can have 2GB from ewach stick in dual channel and the odd 2 in the 4GB stick would be in single channel - else all will run in single channel - and of course that's if they will play together, if you have the sticks and want to try let me know the model #s of the DRAM and what mobo and CPU