They're both good cards with identical specs. If you are an avid O/C'er, you may get the Asus a bit higher with its Direct CU II cooling. I've used both manufacturers cards over the years with no issues at all. I have just installed the R9-290X version of the Asus Direct CU II card in my system, but it is too early to evaluate the O/C potential. (I'm still waiting on the liquid cooler for my processor)