On Paper, with a dedicated card, you should do fine. Having said that, MSI is nit my first choice of Motherboard. ASUS, ASRock, and Gigabyte are my boards of choice. FSB pretty much quit being a factor when the Core i stuff came in. The architecture is different form those before. It is listed in some places, but that is not something I pay much attention to. It used to be that if you had a Motherboard with an 800 Mhz FSB, then your processor couldn't be more than 800 Mhz FSB. If you have a Motherboard with a socket rated at 800Mhz and use a Processor rated at 1066 Mhz, It 1) may not work or 2) if it does, you willl have a processor that can put out more then Motherboard can handle. The FSB is directly related to the processor. It is the "Pipe" that the information from the CPU goes down so to speak. If that pipe is smaller ( 800 Mhz ) then the CPU ( 1066Mhz ) it will get bottlenecked. At least in theory. Memory is a whole other thing.