There is a big difference. I too would recommend a full SSD, but as you say, that is not an answer, so I'll hold back on that.
SSHD's, or 'solid state hybrid drives' are a combination of SSDs and HDDs. The SSHD's you are looking at have 8 GIGAbytes of SSD memory. Then what is the 16/64 MBs of cache you say.
All modern hard drives come with DRAM cache for high speed transfers of small files. WD/Seagate/Toshiba, they all have them. This cache is REALLY fast. Faster than the 8 gigs of SSD on the drive. Thus, for small file transfers, the 64MB cache drive will be MUCH faster than the 16MB cache drive.
Thus, I recommend the 64MB drive.
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Now I will explain in detail why I recommend full SSD. Don't read if you aren't interested.
There is very little fast everyday data that you use. Much less than 128 or 256gb. Thus, if you keep your fast everyday data on a full SSD, and 'bulk' data where the speed doesn't matter on a normal hard drive, you can create a fast yet still high capacity machine.