Just out of curiosity, is it affecting your usage of the computer? Had an odd situation with Firefox a year or two ago running on an older box (Intel C2D with 2gb ram) - it would have a memory leak situation where Firefox would start locking chunks of memory until the computer was completely unusable due to zero memory available.
Yes, locking open 4gb of memory seems like a lot, but the memory manager in Win7 is pretty good, and it's only using a quarter of what you have. Unless it starts locking open bigger chunks and creating performance problems, I wouldn't worry too much about it. If you want to check your usage (as in what programs are using what memory):
Right click on the taskbar, select 'start task manager'
Go to the 'processes' tab
Click on the 'memory' header - it will sort by memory usage
use that to see what is locking up the most memory. Perhaps some programs are running which are unnecessary at startup and you can disable them (and that would be a whole different post).