The major difference between the 6121 and the 6141 is the number of carriers it CAN potentially bond. the 6121 supports 4, and the 6141 supports 8 on the downstream I think both only support 4 on the upstream. but this is limited by the plant your in and what the cmts allows it to bond to as well. For instance where I work when the 8x4 modems first were coming out we only had 4 carriers available so you'd only get 4. Is there an advantage to using 8 over 4 channels, only for the power boost speed and balancing out the load [which if 4 won't do it you most likley have a cable damaged and it won't actually help to have 8.
The incompatibility with comcast's netowrk I reserve for visual verification I hear people say we have problems with modems all the time, then I look and the people just have shitty cable in their house because they did not want to pay to get it updated, etc.. It's funny they will buy $500 in modems and routers but refuse to get the 4 lines replaced for $100. or my favorite its the landlord's problem: ok, but your modem is on it and he's not going to care.