The GTX 780 Ti Classifieds are an easy choice, and as a Nvidia owner, you are probably already aware of some of the unique tech they offer including HBAO+, PhysX, Adaptive VSync, TXAA, FXAA, Geforce Experience, Shadowplay, and great driver support. You would lose all that by going with the 295x2.
A couple other considerations:
1. Sure many of the reviews of the 295x2 have shown great performance, but at 1440 resolution it would most certainly be slower than a pair of top-end GTX 780 Ti Classified's. Most reviews are comparing the 295x2 to the stock version of the 780 Ti. Classifieds, as you know, are much faster than the stock models and the 295x2 really tended to take a lead only at multi-monitor resolutions. At your resolution, the 295x2 is actually not much faster than a single GTX 780 Ti. The big concern, however, with those 295x2 performance numbers is the fact that AMD has a well-established track record of supplying reviewers with cherry-picked samples that significantly outperform their retail versions. I would be very wary, even expectant, that would happen again.
http://www.tomshardware.com/reviews/radeon-hd-7990-crossfire-overheat,3539-2.html
2. While there has been a lot of positive written about the 295x2, it hasn't all been positive. Here's some of the caveats TechPowerUp listed in the conclusion to their 295x2 review.
http://www.techpowerup.com/reviews/AMD/R9_295_X2/30.html
Quote:
"Yet unlike a single GPU card based on two graphics processors, the R9 295X2 needs good drivers to show proper performance improvements in games, and AMD's updated driver support produced better CrossFire scaling across our test suite than ever before. The only game that does not scale properly is Diablo 3: Reaper of Souls, which marks a significant improvement over the last time we looked at CrossFire with the HD 7990, where six out of eighteen games did not scale as expected. It still shows that you may be left with single GPU (R9 290X) performance when a new title comes out for which CrossFire support is not available immediately. Also, at lower resolutions, 2560x1600 and below, scaling is slim in general, and I would not recommend the R9 295X2 or any other multi-GPU solution for those setups. A powerful single-GPU solution, like NVIDIA's GeForce GTX 780 Ti or Titan, will definitely do better at 2560x1600 while being more cost efficient.'
"At full load, the watercooling radiator also gets quite warm; you won't burn yourself, but it will feel hot to the touch. The 500W+ heat output will definitely warm up your room, and there is no way around it as the heat has to go somewhere. While many might say that the 120 mm radiator is too small, it does a fine job and keeps the card at good temperatures, but does so with a little too much noise. Temperatures under load are around 60°C, so AMD could have, in my opinion, run the fans slower to reduce fan noise."
"A second fan is installed on the graphics card itself, and its job is to cool voltage regulation circuitry and memory chips. This fan has to work incredibly hard and tends to be noisy. I also wonder whether this part of the thermal solution is designed properly. Under full load, our new thermal imaging camera reveals that the backside of the card reaches over 100°C as heat produced by the VRM circuitry on the front travels through the card, which means the components on the front are even hotter. Taking a closer look, it seems as though the heatsink fins under that fan are facing the wrong way as they direct air to the sides and onto the walls of the waterblocks instead of up and out. AMD should have maybe used a single, full-cover block that cools all components to avoid such problems."
"Another surprise is that the card still produces some coil noise (listen for the chirping noises in our thermal imaging video). While less pronounced than with the HD 7990, it is still there. After all the HD 7990 drama, I expected AMD to make absolutely certain it wouldn't happen again. Depending on the situation (FPS, game, and load), coil nose also changes in both volume and frequency, which, at times, makes it incredibly distracting and very difficult to ignore. I find the R9 295X2's acoustic footprint higher than what would be necessary, especially in idle. The card runs at noise levels comparable to other high-end cards that are obviously slower under load, but I feel AMD could have optimized things a bit better. With current drivers, the card has absolutely no fan control or fan speed monitoring, so you can't even just adjust things on your own."
http://www.techpowerup.com/reviews/AMD/R9_295_X2/29.html
"Now, let's look at power consumption. As expected, power consumption is high, really high. The R9 295X2 generously sips power in even non-gaming states since the two pumps and fan on the radiator require power at all times. You should expect around 500-600 W of card-only power draw while gaming, which means that you can't cheap out on the power supply. 750 W is, I'd say, the absolute minimum, and 900-1000 W is better if your other system components are high-end too. AMD is overdrawing the PCI-Express 8 pin connectors. Instead of a maximum of 150 W per connector, they are pulling more than twice what is allowed in the specification. While it's not uncommon for overclockers to do so, I'd like to see a third 8-pin connector instead. And yes, the power cables get warm to the touch."
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