I have an unlocked CPU and z mobo. I'm currently OC to 4.3, and yes, I can tell the difference from stock speeds.
The Buss speeds are a central speed that is used by the CPU and your RAM. Normally for an Intel it'll be 100.0 If you raise that, not only will your CPU get OC, but your RAM will too. It also affects all communications between various components that use the FSB. AMD has an easier time with FSB OC, but for Intel CPUs this can cause a multitude of problems, the least of which is CPU instability.
Leave the FSB at 100