Booting off the SSC will definitely make a difference. Playing games off a regular HDD is ok, but if you have enough room, I would suggest installing your most played games on the SSD as well. I have 3 games, that I play on a regular basis, installed on an SSD. It does make a huge difference on load times, but I am guessing that depends on the game too. Guild Wars 2 makes map switching so much faster off an SSD.