I can't open .exe programs or run anything

For some reason when I try to open any program it says that i need to choose what to open it with can someone please help.

I can't seem to type regedit or enter command prompt either.
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More about open exe programs run
  1. I would scan for adware/malware/virus.
  2. Try to roll back your windows using system restore.
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Command Prompt Windows 7 Regedit