Gaming from secondary internal drive?

gtgm_110

Honorable
Feb 7, 2014
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I have a 1TB HDD that I use for Windows, and I have a 500GB HDD that is formatted to NTFS, but is empty. Would I have any performance loss by playing games installed from that secondary drive? Both of my drives are 6 GB/s and are in the primary Sata slots on my MOBO