Personally I like the look of the inside of the case the layout that is. However, you get no dust filters what so ever which may make the dust thing an issue if you don't have canned air or something else to eliminate the dust.
Maybe something like the arc midi r2 would be more of what you are after. and then the Fractal Design Define R4 or XL for full tower if you wanted more of a silent setup. In any case though for Airflow you would want optimized fans if you really care about cooling. I know linus from LTT he tends to swing towards the NF-F12's for all the fan slots however you could always go the radiator route with those and maybe af140's/120's depending on the case of course.