I had no problem with upgrading from an AMD Athlon II 4850e (AM2) to a AMD Athlon II x4 630 (AM3) on my Dell Optiplex 740 DT edition with the Enhanced BIOS. While I had success there, am not sure it would had been the same in a non-enhanced system.
Oh, and the performance of a true quad core (no H/T) or gimmicks is like the difference between day & night. Windows 7 ran sluggish on the dual core 4850e (an 'energy efficient' CPU), on the 630 x4 is kicking some tail, though one of the specs (I believe HyperTransport) is not at full speed. Still, a true quad is better than a dual core, both operates at about the same frequency. BTW, the 630 x4 was among the first line of AMD quads, the 620 was $99, mine was $10 more, and there were a couple of others.
Gave Intel a run for their money!
Cat