pcie 2.0 with pcie 3.0 gpu?

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May 28, 2014
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let's say that I'm using a board that has 1 pcie2.0x16 and 1 pcie2.0x4 with xfire support. Should I use both slots with 2 3.0 cards or just one gpu in the x16 slot? What is the best pcie setup in this case to maximize performance?