It should work when installed in the Windows non-emulator WINE in versions up to Mint 16, but not Mint 17. Diablo 2 requires the Hardware Abstraction Layer (HAL) which has been deprecated (obsolete) and is no longer available. Well, I could be wrong... but it doesn't work with XUbuntu 14.04 which is the foundation for Mint 17. Also the desktop environment you choose can affect the functioning of Diablo 2. On my hardware the Mate desktop and XFCE desktop seem to work well while Cinnamon behaves squirrily.