Update your GPU's driver. Update all of your MOB's drivers.
Update Windows. If you have any OC disable it.
If it has it, update the game. Run a virus check. (You never know)
Use MS Security Essentials.
http://windows.microsoft.com/en-us/windows/security-ess...
Make sure your system is running cool. You can use HWMonitor to check your temps.
http://www.cpuid.com/softwares/hwmonitor.html
See if your GPU has problems.
http://everydaylife.globalpost.com/signs-symptoms-faili...
http://www.howtogeek.com/174068/how-to-identify-which-h...
Check the PSU. When one fails it can cause tons of problems.
http://pcsupport.about.com/od/toolsofthetrade/f/powersu...
Run Resource Monitor and see what your workload is.
http://www.pcworld.com/article/241677/how_to_use_resour...