So this problem has been going for a while now (maybe about 4-5 months now) and I've learned to deal with it. But it's gotten to the point where I cannot stand it anymore.
My sound crackles and my computer's performance tanks whenever I'm doing things such as: Watching twitch on fullscreen, playing DOTA 2, watching a fullscreen movie on VLC, etc. If I remember correctly the sound crackling started when I installed my new graphics card and I was tinkering around with my new monitor. Since then the crackling will not go away no matter what I do.