IF they will play together, which can be a big IF, in most all mobos, you would want the 2GB sticks in 1-3, and the 1 GB sticks in 2 and 4, that way you have 3GB in each channel, if you were to place them as God-father-board said you'd have 2 GB in channel A and 4 in channel B and in best case scenario you'd have 4 GB in dual and 2 GB running off in single channel which you don't want, added stress on MC (memory controller) and prob additional heat as it wouyld prob require extra voltage o run the sticks mismatched that way