it can, as long as your motherboard has a PCI express 16 slot. That said, it will be not a optimal setup, because the 780 ti will be bottlenecked by the and cpu (APU) and will not achieve its full potential.
Don't really help but, just open your case and look for a pci-e x16 slot.
And most motherboard have it, so you should be fine but just check to be sure