ANY time you mix DRAM, it can be and often is Problematic - even when you buy the same exact model...Mixing sticks from different packages isn't recommended. And contrary to the above comment, no the slots aren't made for 'different pair', on a dual channel mobo there is channel A and channel B each supports two slots, typical config is A1 and B1 or A2 and B2, one stick in each channel and the purpose is to enable dual channel. Each stick of DRAM by itself is a 64bit device, when dual channel is enabled then the 2 or 4 sticks that are populated are seen as 1 single 128bit device and run accordingly, they are aren't looked at and treated separately as in implied above. Further if you were to peruse the forums here and elsewhere, you will find the same thing over and over again, of people following the above "advise" and mixing sets of DRAM, only to find their rig won't boot, or gets BSODs galore, etc....simply because the sticks don't want to play together. It's always best to buy a single set of DRAM of the full amount you want/need, rather than face the possibility of RMAs, shipping fees, etc... Either go 2x8GB or if have doubts of needing that much a good 2x4GB set