It's best to OC via the BIOS. Start by increasing the CPU's clock multiplier one click at a time. Test for stability. I use Intel Burn Test for working up my initial OC:
http://www.techspot.com/downloads/4965-intelburntest.html Most of the OC will be obtained via the multiplier.
If it passes the default 10 pass run, you can go back and take the multiplier up some more. Repeat the stability test. Eventually, you will reach a point where it is unstable. You can then either back off and live with that OC or go back into BIOS and increase the CPU vcore (voltage). That will usually allow you to keep going for a bit more with multiplier increases. Personally, I don't like to take the vcore up too much. I'd rather live with a mediocre OC than over tax the components.
Your MB is a good board, but not one of the high end OC'ers. So don't push the vcore too high. When you are at what you feel is where you want to be, run prime95 for at least one full hour... overnight is best. Some stabilities won't show up until the components/board get really warm for long periods.
http://www.mersenne.org/freesoft.htm