Do any of the powerful graphics Cards come

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You mean taking up a single expansion slot? I actually don't know of a R9 280X, R9 290X, or GTX 780 that takes up a single expansion slot. If I am misunderstanding the question, I apologize.

If you go a custom water cooling route, you can remove the cooler block and replace it with a custom water cooling block, then it'll take up one PCIe slot. It will still cover up two expansion slots.
You mean taking up a single expansion slot? I actually don't know of a R9 280X, R9 290X, or GTX 780 that takes up a single expansion slot. If I am misunderstanding the question, I apologize.

If you go a custom water cooling route, you can remove the cooler block and replace it with a custom water cooling block, then it'll take up one PCIe slot. It will still cover up two expansion slots.
 
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jnewegger23

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Unfortunately the answer is no and most likely you are asking to put into a retail cpu like a dell which are compact and that's fine but the psu's will be severely under powered typically. If that's not the case (no pun intended), then consider Extended ATX mobos for your custom rig and a full tower if heat and spacing are you major concerns so you can alternate spots for your sound cards and so forth to be placed further away with having the extra slot spaces. If it's neither please fill us in as to what's behind the question so we can better help you and like others said you can go single slot with custom water cooling. Hope this helps!

Thanks,

Justin S.
 

WINTERLORD

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Sep 20, 2008
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well I was thinking of a micro atx board to handle atleast 2graphics cards but noticed if I did that there would be zero slots to expand on in the future. although I upgrade fairly often I like to be able to expand wanted to stay in a micro atx for factor but might do otherwise
 
Well, there's not much to expand to. Three-way GPU configuration scales terribly. So the only thing that you may add is a sound card. I'm sure there are other PCIe hardware that you can plug in, but it depends if you need them. You can definitely stick with Micro ATX. Some of the high end Asus motherboards have really good audio. Maybe worth investing in one of them if you want to keep a small form.