To be perfectly honest, Skyrim is NOT a demanding game. I maxed it out on a Radeon 5570, 6GB of RAM, and a Core 2 Duo. It's not a hard game to run. You theoretically should, but keep in mind every system performs differently and you'll never get the exact same performance as someone else with the exact same components.
Honestly I'm now curious as to why you'd want to play games with 3 monitors anyways. You really should invest the money in 1 large monitor and 1 small side monitor instead of 3, since 3 gives you stretched peripheral vision and it also reduces performance quite a bit. It distracts you too much, and FPS games and whatnot should really be played on a single large high-res monitor.
You've already bought them so ignore the last part, but since you're here you probably read it.
Skyrim will probably run just fine, but I have a 660TI and I can't run Skyrim at ultra 60FPS all the time (which AA turned up and the works). Beware that not every system runs the exact same way.