Programs put entries in the registry so they must stay on the same drive.
If you buy a Samsung ssd, they have a free migration clone utility that works with their drives.
A new version allows you to be selective as to what to move.
If your windows, programs, apps and such will fit, you are ok. The data files can stay on the old hard drive and the windows and program files can then be deleted from the hard drive.
Here is a link that describes that capability:http://www.samsung.com/global/business/semiconductor/minisite/SSD/global/download/11_Samsung_Data_Migration_Software.pdf