I'm running games, like Assetto Corsa, iRacing, War Thunder, etc.. with two XFX Core edition R9 290's in crossfire at 7680x1440 (three 27" 60Hz monitors). I have changed the setting on the Catalyst 14.7 drivers to allow the R9 290 fan speed to go up to 100% if needed (they get loud!), while keeping the standard clock and 94C max temp settings.
My PC is a 3570K with 16GB ram on an ASUS Z77 Sabertooth, no overclock.
While running Assetto Corsa, If I turn off frame rate limits and v-sync, I can get up to ~120fps at times with lower settings for the AA & AF and reflections. But the R9's will go to full fan speed and 100% usage, along with the CPU cores. Also the frame rate will vary enough that it causes some lag on screen.
If I use v-sync in Assetto Corsa, then I get a constant 60fps and the physics and lag feel much smoother/better.
I did notice that I use 100% of the ram of the 4GB on the R9 290 (in crossfire).
If I try to run a race against other cars, then I really have to turn down the detail to get 60fps when other cars are on the screen!
One thing to keep in mind is that Display Port would require an MTS hub to run 3 monitors off the one plug... BUT!!! Display Port CANNOT do three 1440p monitors! DP can do 3x1080p monitors, but 3x1440p monitors requires too much bandwidth!
I have my 3 monitors hooked up, 1 to DP, 1 to HDMI-highspeed cable, 1 to DVI-dual link cable. You could try 2x1440p monitors on DP, but then you would have to buy a $100-150 MST hub, and then you could use the 2 DVI ports and 1 HDMI port (on an R9 290 for instance).