it is compatible with that motherboard bcuz its DDR3- http://www.asus.com/Motherboards/M5A97_LE_R20/specifications/
-but DDR3 2133 O.C. means ur going to have to overclock ito get it to run that fast, the mb supports overclocking it. The more ram the better it doesn't matter what speed. I wouldn't overclock if u don't know what ur doing, u could ruin parts or make the room feel like a sauna.