You probably could at the very bottom PCI E 16x running 4x. If only the PCI E 1x slot is at the very top it won't be a problem. But i would recommend looking at what Asus has to offer at the same price point. I'm currently having a lot of problems with my Gigabyte mobo. But are mobos are hundreds of dollars apart from each other, so you might not get the same problems as I and the others that have the same mobo as I do.