That motherboard has 4 slots, so 1x8 doesn't really provide you much of a benefit. Get 2x4 now and if you need to upgrade down the road, another 2x4 later (it's unlikely, unless you have very specific needs that you'll ever need more than 16GB before you swap out the motherboard). The 2x1s aren't really a factor - there's not really much of a benefit to using them at all given that the difference between 8 and 10 is nearly irrelevant and mixing and matching RAM is a frequent source of nagging, obnoxious PC issues.