Do you have it, or you are considering buying it? If you already have it, it wont hurt if you try to run a game off of it.
Otherwise, I would recommend you to get a USB 3.0 device. Another thing you should consider is that the heavier the game, the harder for the drive to keep up with the data transfers and the loading times.
I have it and played Warframe on it and I was having problems so was just checking that it was hdd or my gpu I got a new one now I will check if the problem persists