Hello... the USB connection is the problem... it does not come from the Realtek Audio output/effect that you are using... The software "effect" that you are using comes from the realtek hardware and must be connected to the realtek output connections to hear the "effect".
If you have another piece of Audio Playback equipment in your Room, you might be able to use a 1/8" stereo sheilded cable to connect to it, from your realtek outputs.
Other wise return them for Powered Speakers with a RCA/1/4"/1/8" input jacks.