All flash drives becoming corrupted

So I should run all four programs, one after the other? Or choose from one of the four? (Antispyware, Avast Antivirus, Spybot Search and Destroy and MalwareBytes). There is definitely something going on, because now everything is getting really laggy, and it's doing the CHKDSK thing. I ran the command prompt to check the disk yesterday, which took a couple hours and thought things were better, but there's still lag issues.

Going to run MalwareBytes whilst waiting on an answer to this. It came up recently as a suggestion, so I'll do that one first.

Alright, thanks guys. I downloaded all of the above programs and ran them and they found some stuff, but now a second issue is occurring that is probably unrelated, but who knows. I got a CHKDSK error about a week ago and it did the whole verifying indexes, deleting index entry, correcting error in index, etc etc for about five minutes before starting up. Now this makes me EXTREMELY nervous, because the computer is now crashing occassionally with the CHKDSK error and yesterday after installing Windows Updates it didn't want to start Windows back up. This is a home build, and I'm already on hard drive two, since the first one failed on me and was doing this exact same thing.

To complicate matters further, a Windows Update nerfed BOTH my computers yesterday, messing up the drivers among other things, and I'm still unsure if some of the stuff is virus-related that we didn't catch or if there are complications from that update. Then I've got to weed out if my other computer is freaking out because of a virus or if the hard drive is failing.

So should I start a new thread for the CHKDSK thing? It's the same computer that's frying all the thumb drives, including my phone which that computer started saying it couldn't recognize the device, and so I put it in the other computer and the same thing was happening. Also, both computers are on a network, and can viruses spread from computer to computer over networks or not? I'm such a newb... also could I have spread the USB virus over by plugging my phone into the other computer.

All your edu-ma-cationing of my newb self is greatly appreciated, so any infos on this would be great.

Oh one more thing: Avast is acting like a virus itself! I asked it not to install a desktop icon, it did anyway. I said I didn't want my computer monitored, yet it fires up at start up. One of the problems I'm having in trying to work on this computer is every time I go to restart it I get an Application Error that avastui.exe was unable to start correctly and when I try to remove the program my computer says it can't! Freaking annoying as hell. And to complicate things further, I tried to do a restore after the Windows Update nerfed things even more (my graphics driver has disappeared, so everything is HUGE) and all my restore points have completely disappeared.

Update: Got the driver issue worked out, so graphics back to normal, and reinstalled Avast, which allowed me to uninstall it. I'm going to go ahead and start a fresh thread for the CHKDSK error. Will try to make it back here when I've got something to report on the USB ports. Thanks for all your input!

FYI: Using all of these anti-viruses, one after the other, has really resulted in some gnarly issues with my computer. In short, the sh*ts broked. Working with malwarebytes support to sort it out, and haven't got any CHKDSK errors in a couple days, so it was probably a virus, but wanted to post up here thta people should beware using those programs one after the other, because for me it created a major mess.