VRAM is NOT an issue with non-gaming monitor. Unless the GPU needs to render frames (which it hasn't have to do so vigorously with secondary monitor), it will not affect FPS in any way. You can keep a secondary 1440p monitor running Youtube at same time while running Crysis3 on primary 1080p and you'll not see any considerable frame drops. 1-2 FPS maybe.
You can't game on two monitors at the same time, imagine where the cursor will be in FPS games. You however can mirror the game's image on secondary, which again will not take away VRAM as it's just a copy paste and nothing's being computed. A 128MB video card can run a 1440p monitor just fine, VRAM becomes an issue while gaming, where GPU needs space for data to be put quickly for rendering and developing frames and transmitting it to the monitor. When not gaming, it just needs to pass on the data and frames to the monitor, which doesn't take any considerable amount of VRAM.