It will probably increase your OC potential slightly, but the performance difference in gains won't be very large. FX CPUs do not scale well in performance from overclocking, for some reason... overclocking from 4GHz to 5GHz results in maybe a 10% increase to performance in most applications. Moreover, one of the benefits to having more cores is that background applications don't get in the way of gaming applications as there's more room to spread around the tasks. I don't think you'd see any performance increase from disabling 2 cores for extra OC headroom.
Also, disabling 2 cores wouldn't be the difference between 4.5 and 5GHz unless you've got a really limited CPU cooler.
What I'd suggest giving a try is overclocking the northbridge rather than purely the highest clock speed possible. It improves the memory and cache performance somewhat which is one of the areas where FX CPUs struggle.