I would only recommend using XFire/SLI for the top 2, maybe 3rd card from each side (not counting dual GPU cards), anything less than that you are better off with a single card, the performance difference diff between two mid ranged cards and a single high end card, especially if the former is from generation before, is not large enough to warrant the SLI issues.
General rule is: if 1 card can get the job done, get 1 card. Use SLI/Xfire/Dual GPU only when the settings/resolution you want to use cannot be achieved with any single GPU card on the market