Greenpedro5 :
there is no real way to do this but you could purchase a usb 3.0 pci e card and have the flash drive running off the internal usb and always have the priority boot order as usb first if your using linux that is easy. there is a link to how to do this with windows.
http://lifehacker.com/how-to-run-a-portable-version-of-windows-from-a-usb-dri-1565509124
That is actually easily doable with Windows as well. Hell I was making XP flash bootables years ago.
OP, That USB drive is only capable of up to 100MB/s per SanDisks website, and that is maximum which could drop due to encoding and file size. I don't think it would benefit your system enough to justify using it even as a ready boost drive.
Why not get a 128GB SSD? They are pretty darn cheap these days.