The only way to find your optimal setting is to try for it with trial and error;
Your only limiting factor is temperature.
The higher you boost your clock, the more voltage you will need, the hotter the card will run.
Under normal circumstances EVGA Precision X will balance this out for you.
clock to voltage ratio varies from chip to chip; and cooling effectiveness depends on your PC case (airflow) + Ambient temp (in a small measure)
Running it too hot can damage your card and shorten its lifespan.
95°C is the maximum temp for your GPU;
I would aim for an absolute maximum 80°C or less under load, just to be safe.
Boost your clock as high as possible without exceeding this temperature under load, and you will have your optimal setting.
make sure to keep an eye on your temps, especially in the beginning.