Give it a try, might or not play together, would put the 8GB in slot 1 and the 4s in slots 3-4 to try and keep dual channel, if any problems let me know and we can try adjustments to get them to play - if they play from the start (prob 1066 or 1333 depending on mobo) might be able to get them to 1600 - let us know the model numbers