Enricowals,
If you work on big files, my advise would be to look for a Supermicro X10SRA or Gigabyte MW50-SV0 motherboard, and install either the E5-1620 V3 or E5-1650 V3. Start with 2-4 X 16GB DDR4 ECC RDIMM's. With current DDR4 density, these boards and CPU's will support up to 128GB memory, but with future densities they will support up to 512GB. Add more as needed
If you never wind up needing more than 64GB it's no big deal, but at least this configuration will always have the option. The 1150 socket platform only supports up to 32GB, and the X99 chipset on 2011-3 socket boards only supports up to 64GB.
If you work on smaller projects, an E3-1231V3 on a C226 chipset motherboard with DDR3 ECC UDIMM's or i7-4790K on a nice H97 motherboard (like the Asus H97 Plus) with Kingston/Crucial/Mushkin memory would be nice.