If you put two 2 GB sticks in channel A and two 4 GB sticks in Channel B as you said you have 4GB in A and 8 GB in B - that would result in all running in single channel or at best if the mobo supports flex you'd have 8GB in dual and the odd 4GB in single. You have to split the sets with a 2GB and a 4GB in each channel. ANd then it will be dual channel IF, BIG IF, the two sets of DRAM will even play together. Any time you mix DRAM i can be an doften is problematic, even if they are two identical sets of DRAM, using different amounts, brands, timings, voltages, etc can just compound the possible problems