DDR3 dimms have the same pins layout whether they are unbuffered or ECC as far as I know, and I believe you can use either with a compatible processor (e.g. Xeon) and motherboard.
Desktop motherboards and processors support only unbuffered memory though, so you cannot use ECC memory with these boards.
I have an AMD system though. Xeon surely is not on that list. Do all AMD CPU's support ECC?
I've only seen Intel Sabertooth motherboards, I guess Asus uses this for a lot of different boards.
Desktop AMD processors do not support ECC either, but their Opteron processors would.