In addition to the process recommended by Ralph, let me suggest another option for your consideration...
1. You would first create two partitions on your 2 TB USB external HDD - presumably one partition of 250 GB and a second partition covering the remaining disk-space of the 2 TB HDD.
2. Using the disk-cloning program I strongly recommend, you would clone the contents of your 250 GB SSD to the first partition of the 2 TB USB external HDD.
3. Then clone the contents of the 1 TB HDD to the second partition of the USBEHD.
4. Assuming one or both of your source drives contain an OS you would be able to boot to the OS on whichever partition on the USBEHD that the OS resides should you desire to do so. And, of course, all the programs & data contained on the USBEHD are instantly accessible.
5. Assuming you want to retain that 2 TB USBEHD for future comprehensive backups of the new system that you are contemplating, you could use the disk-cloning program as the vehicle to accomplish that.
The disk-cloning program I recommend is the Casper program. The program is extremely user-friendly with an easy-to-understand interface and straightforward design. No "learning-curve" of any consequence is necessary.
But the chief advantage of Casper is its rather extraordinary speed (in comparison with other disk-cloning programs) in undertaking its disk-cloning operations when the program is used routinely and frequently. This makes the program an ideal vehicle for a user to maintain up-to-date comprehensive backups of his/her ENTIRE system since the user now has a strong incentive to do so because he/she knows it will take only a short period of time to complete the disk-cloning operation. As an example, I back up my PC systems at least 3X a week, sometimes even daily. It usually takes me under two minutes to complete a disk-cloning operation - frequently under a minute when I clone on a daily basis. Naturally the volume of data that's cloned, the user's system, the types of drives involved in the disk-cloning process will all have a bearing on the expenditure of time to complete the disk-cloning process.
Now to the negatives...
The program is a commercial one - it costs $49.99 and AFAIK can only be obtained from the developer - http://www.fssdev.com. I realize that most PC users are exclusively interested in a "one-shot" disk-cloning program to clone the contents of an older HDD to a new larger HDD or SSD and are simply uninterested in using a disk-cloning program as a comprehensive backup tool. More's the pity but that's the situation. So the PC user can obtain disk-cloning programs that are freely available on the net and by & large they will do the one-time job. No doubt the program Ralph recommended is one of those.
All I can say is that I've never found a disk-cloning program as effective, reliable, easy-to-use, and as fast in carrying out its disk-cloning operations as the Casper program. So if you have an interest in using such a program for carrying out comprehensive backups of your system so that you can maintain up-to-date bit-for-bit copies routinely of your PC system give this program some consideration.