I cannot find anything about that MB. Are sure that is the correct model? I get "zero" matching results when searching at MSI's web site. And as long as there is a x16 PCIe slot and there is just more than the 10.5" in room iside the case where it will be installed in the case, the GPU will fit. You will need a really good CPU with a GTX 980, or the CPU will bottleneck the GPU.