If you have the monitor yes it can, though you'll have to dial back settings on some games. AMD version of DSR doesn't work like Nvidia; so if you've got a non-2160p monitor and you're trying to run 4k it won't work; your max res will be 3200x1800 unless you have the R9 285 I think (so weird). For 4K I'd recommend Xfire 290Xs.