Both can run it fine, and about the same. My R9 270 did very well with it, And it would have maxed it out if it had more V-Ram, And my GTX 970 crushes it. But yes it is fine with AMD cards . Except the MSAA artifact problem some people get. But using catalyst driver 14.4 solves that problem. And it is fine with Nvidia. And the same for CPU's I have no idea why people claim GTA V uses lots of CPU power. GTA V hardly stresses the CPU at all. So any CPU from AMD or Intel dual core or quad core will be fine. I still have my old i5 750 sitting next to my newer PC, And I tested the Ivy i5 and the first gen i5 with a 9800 GTX+ and a 650 Ti, And a R9 270 and a GTX 970, Both CPU's performed about equal with each GPU. And the more powerful the GPU the less the game needed to pull from the GPU. So honestly this game is not very demanding at all. It is just not well optimized. But because it is not very demanding this helps make up for it's poor optimization. I would really like to see Rockstar patch it some more! But it looks like all they cared about was just getting it running. But even people with old RV770 and G80 and G92 GPU's can run this game.