Hey there, RubbeHill.
The short answer is - yes, this is possible. I gather that you want to speed up your storage drive for gaming or demanding software?
Take a look at this thread here: http://superuser.com/questions/323959/is-it-possible-to-use-one-large-ssd-as-both-system-disk-and-intel-smart-response. It's a bit old but still relevant.
Hope that helps.
Boogieman_WD