I wouldn't do it, honestly i think it's a waste of money. Games hardly support even 2x crossfire not 4x...
Anyway i advice you to sell your 295x2 and look forward to PC Gaming Show 06 15, where the new flagship cards with HBM will release form AMD. IF you want AMD then go that route and get 2x of the new flagship cards.
other route is 2x 980ti, which i think is the best by the way.
If you want to stick with the 295x2s anyway its possible on that mb , but you'll need a very strong and high quality power supply, since 1 295x2 uses 500watt... so 2 uses 1kw...