They cannot be used in SLI. Even some cards from the same family can't be used in SLI if there are differences to the memory architecture and absolutely can't be used together if they don't have the same GPU architecture. As far as using them together WITHOUT SLI, sure, but not in combination for help with gaming unless you plan to run the desktop on one monitor using the lower end card and game on another monitor using the higher end card connected to that monitor.
That might offer SOME benefit, if you were currently displaying the desktop or other applications on one monitor and gaming on another monitor. To use them together to try and increase graphics processing horsepower, no, that cannot happen.
You're also going to need a much bigger PSU to run both those cards. Any PSU that was capable of only running one of those cards is not going to be sufficient for running them both. You'd probably need a 900-1100w unit, maybe could get by with a very good 850w unit, to run both those cards independently.