First off, if you dont want to lose your data then it needs to be backed up because any of your drives could die at any instant and you need to be prepared for that.
Now onto your problem, It may or may not work. OEM like HP,Dell... even if it does intitially work will eventually fail Genuine Advantage check once it compares the bios's motherbd model# with what its expecting to see. A system builders oem, like you would buy from Newegg when you buy system parts, might work if the drivers are compatible and I dont think you'd have an issue with GA. I cant recall a builders oem failing GA after a motherbd replacement repair.